Cochrane Database Syst Rev. 2013 Feb 28;2:CD000528. doi: 10.1002/14651858.CD000528.pub2.


International Health Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK, L3 5QA.



Schistosoma mansoni is a parasitic infection common in the tropics and sub-tropics. Chronic and advanced disease includes abdominal pain, diarrhoea, blood in the stool, liver cirrhosis, portal hypertension, and premature death.


To evaluate the effects of antischistosomal drugs, used alone or in combination, for treating S. mansoni infection.


We searched MEDLINE, EMBASE and LILACS from inception to October 2012, with no language restrictions. We also searched the Cochrane Infectious Diseases Group Specialized Register, CENTRAL (The Cochrane Library 2012) and mRCT. The reference lists of articles were reviewed and experts were contacted for unpublished studies.


Randomized controlled trials of antischistosomal drugs, used alone or in…

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