New Drug Approvals

TLC388 (Lipotecan®) structure can be figured out from a link below of a poster

http://www.tlcbio.com/files/news/2011111701580783.pdf

IT IS A CAMPOTHECIN ANALOGUE

The str can be concluded from above picture from a poster by TLC BIO

TLC388 (Lipotecan) is a potent Topoisomerase-1 inhibitor and it can disrupt both Sonic Hedgehog and HIF1-α pathways to overcome cancer drug resistance and inhibit angiogenesis induced by tumor hypoxia. This phase I first-in-human study of Lipotecan examined the MTD, safety, anti-tumor activity and pharmacokinetic profiles of TLC388 in patients with advanced incurable solid tumors.

Methods: Lipotecan was administered intravenously on day 1, 8 and 15 of a 28-day cycle. Patients underwent safety assessments regularly and tumor assessments every other cycle. Pharmacokinetic samples were drawn on days 1, 8 and 15 of cycles 1 and 2 for all treated patients.

http://mct.aacrjournals.org/cgi/content/meeting_abstract/10/11_MeetingAbstracts/A89

http://clinicaltrials.gov/show/NCT00747474

MAR19 2013

China SFDA has granted fast track approval status to Taiwan Liposome company hepatic…

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