New Drug Approvals

ELQ-300

6-chloro-7-methoxy-2-methyl-3-{4-[4-(trifluoromethoxy)phenoxy]phenyl}quinolin-4(1H)-one

21 MAR 2013

A promising new antimalarial drug with the potential to cure and block transmission of the mosquito-borne disease has been discovered by researchers.

The drug, known as ELQ-300, has demonstrated preventative transmission-blocking and a low likelihood of developing rapid resistance to major strains of malaria parasites.

Researchers say it is also likely that the drug could be produced more cheaply than existing antimalarials.

ELQ-300 is now moving into clinical testing.

This new treatment was developed by the Medicines for Malaria Venture (MMV) drug discovery initiative, which is made up of researchers from Oregon Health & Science University in Portland, Drexel University in Philadelphia, University of South Florida and Monash University in Australia.

The full details of their research was published yesterday in the Science Translational Medicine journal.

During the process of creating the drug, researchers discovered and developed a series of potent compounds to…

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